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Cellulitis

Also called skin and soft tissue infection

Bacterial infection of deep dermis and subcutaneous fat: a warm, tender, poorly demarcated, spreading unilateral erythema, usually on a leg, often with fever and a portal of entry.

Spreading erythema and oedema of lower-leg cellulitis
Hover or drag to examine with the dermatoscopePshawnoah · CC BY-SA 3.0

How it looks

A poorly demarcated, warm, tender, oedematous erythematous area over the lower leg, spreading proximally, with a fissured interdigital web space as the likely portal.

Rose is the lesion, grey the pattern the lesions make, green where on the body it lives.

Across skin tones

Erythema is easy to miss in deeply pigmented skin, rely on warmth, tenderness, swelling, and shiny skin; compare with the other limb and mark the border to track spread.

Don't miss

Pain out of proportion, rapid progression, bullae, crepitus, or anaesthetic skin is necrotising fasciitis until surgically proven otherwise, this is a call for the surgeon, not a bigger antibiotic.

Symptoms & course

  • Pain and tenderness
  • Fever and malaise
  • Rapid progression over hours to days

Diagnostic approach

  • Clinical diagnosis; mark the border and reassess
  • Blood cultures if febrile/septic
  • Ultrasound if abscess suspected

Differential, and how to separate them

  • Contact dermatitis

    Favours it: Itch, vesicles, exposure shape, afebrile

    Against it: Cellulitis is painful, warm, and systemic

Management principles

  • Antibiotics covering streptococci and S. aureus per local guidance
  • Elevate the limb; treat the portal (tinea pedis, ulcers)
  • Escalate urgently if pain is out of proportion or the patient is toxic

Clinical pearl: Bilateral 'cellulitis' is almost always stasis dermatitis, cellulitis is overwhelmingly unilateral.

Clinical pearl: Look between the toes: the fungal portal of entry is the most treatable recurrence factor.

Keep going

Try the case: One red legCompare with Contact dermatitisBack to the Atlas